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A large observational study of 121,492 adults age 60 and older found that nitrogen-containing bisphosphonates, a class of drugs widely used to treat osteoporosis, were associated with a 16% lower risk of Alzheimer's disease and related dementias compared with patients who took no osteoporosis medication.
Against patients on other osteoporosis drugs, the risk gap reached 24%.
The study, published in Alzheimer's & Dementia, stops short of claiming the drugs prevent dementia, and the authors are calling for a clinical trial to confirm the signal. The research was conducted in Hong Kong.
Every participant had recently been diagnosed with osteoporosis or had suffered a serious fracture in the spine, humerus, wrist, or hip, and none had previously received osteoporosis medication.
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